![]() ![]() In a pharmacokinetic study, three Lidoderm patches were applied over an area of 420 cm 2 of intact skin on the back of normal volunteers for 12 hours.īlood samples were withdrawn for determination of lidocaine concentration during the application and for 12 hours after removal of patches. ![]() Pharmacokinetics Absorption The amount of lidocaine systemically absorbed from Lidoderm is directly related to both the duration of application and the surface area over which it is applied. The penetration of lidocaine into intact skin after application of Lidoderm is sufficient to produce an analgesic effect, but less than the amount necessary to produce a complete sensory block. Slideshow Lidoderm - Clinical Pharmacology Pharmacodynamics Lidocaine is an amide-type local anesthetic agent and is suggested to stabilize neuronal membranes by inhibiting the ionic fluxes required for the initiation and conduction of impulses. ![]()
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